Wyrmics are my favorite. My favorite character ever was a sword-and-board Wyrmic with heavy investment in Fugus who stacked +healmod to a ridiculous degree (I believe I was regenerating over 300 hp/turn with my nigh-instant infusions at the endgame). The Neverdead was such a harrowing experience, but I won in the end.
Speaking of Neverdead (and sorry for the necro, but it is a bit appropriate, hah!), I am playing a reaver with great blight (and pretty decent physical damage as a backup). The Archlich was at 100% blight resistance, so I figured it was going to be a challenge. But with vimsense, epidemic and curse of vulnerability, I figured I could get her down to 50% or so.
Unfortunately, 100% was the shown value. She was actually at like 140% or so. So all of the above techniques got her just down to 90%.
First point: don't count on 100% really being 100%. Second: inspection should really show 140%, or whatever it really is; people will understand that the enemy isn't *gaining* from damage, but will know that resistance decreases (and penetration?) aren't going to be as effective.
Third: I beat her. Barely.