ToME: the Tales of Maj'Eyal

Applying Duathedien Heart ( blood grasp ) consumes extra turn(s) before selecting the target or if not charged.

This is a common problem with all targeted items.

However it's not consuming an extra turn, the issue is one of order of execution. Using an item uses a turn immediately, if the item requires targeting you target after your turn is used. The result goes something like this, use item, monsters attack, target item, player goes again.