ToME: the Tales of Maj'Eyal

I typically like to run ToMe of my flash drive since I can travel around with it but have found it tedious to cut and paste my character files over to a temp file on my flash drive then back onto the hard disk of the machine I end up using. Is there a way to change the save location to a designated folder on my drive?

Yes, create a junction (windows)... Search forums for junction and you'll find fairly detailed instructions.