I would ask that you read these, and tell me if I understand what I am saying, or if I misinterpreted something. If you have anything to add, please do, any help is very appreciated. I put a few questions I have in green, if you have any ideas of the answers, please share

Vaults
Vaults are very dangerous if not approached with caution, such as opening from a diagonal, and using Arcane Eye for a preview. Large sized vaults are best left till later, a few levels later at least. Small sized vaults can be opened after you clear that level, and have an escape plan. Acceptable escape plans include teleportation runes/charms and movement infusions. Good areas to SKIP vaults are: Dreadfell, Blighted Ruins, and High Peak.
Especially Dangerous Monsters
A few types of monsters that is best to ALWAYS avoid (if possible) are:
Horror (all flavors)
Elite or Random bosses from vaults
Naga myrmidon
(any others I should know about?)
Character Class/Generic Talent points
It is better to grow the trees outward BEFORE upward. Which is to say, especially before heading East, most all talents do not need to be leveled beyond 3. Best to get a new ability to help expand your options.
Especially good Generic Talent tree to look for: Celestial/Light (I'm not sure how to get this outside of luck though?)
Equipment
It is best to have multiple types of charm items, and switch them around as the situation warrants. Some tips: Totem that dispels darkness and detects creatures first, switch slot to a Ward Totem for protection after.
Having equipment/infusions that can clear (or prevent immunity of) status effects are a must. A Wild(physical, mental) infusion is the gold standard for this.
Equipment is not all about core attribute boosting. Think around the corner to when a shield or immunity will be the thing that saves you, since 10% increased damage will not.
(How do I know when MOAR spell power or magic points is overkill?)
(What are some pieces of Equipment you always hope you find, for any class?)
OK, That's the stuff I didn't know before, but hopefully learned this past 5 days. I skipped Alchemist specific stuff, since not everyone reading it could relate.
What do you feel should be added to these? or what do you feel is wrong?