I tried to do so again this time.
It didn't work out very well.


This image was taken with a Screen Zoom of 80%. The problem starts as soon as I go below 100% and only becomes more pronounced as I go lower.
I'm using Windows 8.
For the record, I specifically started a brand new character without any addons and standard tiles sizes, with every option that even looks like it could slow down the game or cause glitches turned off.
While this does not make the game unplayable, as my characters start to progress further, it will become more and more annoying than it already is, as sustains, cooldowns, buff and debuffs will keep piling up on each other and become hidden under the UI.