I've noticed a weird bug. My latest character has a healing amulet, and it has worked perfectly fine. Until i got the Elemental Split talent.
Now, as soon as I use Elemental Split the icon of the amulet turns green in my hotbar (as if it's no longer equipped). If i click the amulet in my inventory, it says "you must equip the item before you can use it" but the item IS already equipped. If I remove the amulet and then equip it again, I can use it to heal. Until I use Elemental Split, then it turns green in the hotbar and it is unusable again, until I remove and then equip it.
This is really annoying, as a heal is usually needed in emergencies, and that's not the time you'd want to remove it and equip it again, losing an entire turn.

(this was moved by me to the right place [I think/hope].)