This may or may not have something to do with what I initially thought the bug was caused by:
Either way, it only occurs when I have Deflect Projectiles running. If the sustain works for other people then I will assume it has something to do with the randomly appearing target selector of mine + Deflect Projectiles.I cast Nature's Equilibrium, hit something for 1700dmg, got the Bigger is Better Achievement, and the achievement window wouldn't go away (something to do with the recourse heal and the window being up at the same time I guess). After hitting spacebar and escape a few times the window finally went away, but the heal target selector never appeared (or was cast).
So along I went on my merry way, until I loaded a new zone, whereupon the keyboard input wasn't working. The only way to fix it was to right click the mouse and "move to", which fixes the keyboard input for undetermined amount of time until it stops working again (not sure what causes it). Also, upon resting or doing certain actions, the green target selector will randomly appear for no reason in particular.
[Edit] The keyboard input issue persists through client restarts, computer reboots, and foul language. It is also unique to that character (new/other chars don't have any problems).