Hey DeathBySnooSnoo,
That is pretty strange. No sure how to help you debug the issue. I myself use spacebar to accept the auto target, and have seen no issues. What other plugins do you have installed if any?
Im using the following addons:
Extended Auto-use (I consider this a mandatory addon, the game playes much faster with it (well...only if the SPACE issue would be solved)),
Faster Run/Rest/Explore (I consider this a mandatory addon because of the current game performance)
Breeding Pit Restoration Project
Lost City of Vulcus
Normaly i had SPACE binded to the "1" key and to "accept action" key, that way I was able to spam the first skill on my skillbar (for instance the "shoot" skill of an archer).
I just unbinded the SPACE from the "1" key. It seems to work again:)
Cheers and thanks for a great addon!