What would help with situations like that would be if every time the player tried to something a status effect prevents, the corresponding box(es) would do something to draw attention. Additionally, if talents on the hotbar are unavailable due to a status effect, the box should flash on mouseover. Maybe they should flash when freshly applied, too (although that might be a bit much). Another possibility would be to have DoT effects flash when mousing over the health bar, but I don't think enough people do that for it to be useful.
- Try to move while pinned? The pinned box flashes.
- Try to use a healing infusion while frozen? The frozen box should flash when the cursor is over the heal icon.
- "You need more mana to use this talent."
- "You need to be below 25% of your mana to use this talent."
- "You cannot be in sight of anyone in a range of 6 or more to use this talent."
- "You cannot have Surge sustained to use this talent."
- "You must remove the 'Impending Doom' effect to use this talent."