Redux is capable of some ridiculous things, especially combined with the Spellbinding tree. Here's
my recent winner.
Matrix+Echoes+Redux will destroy whole rooms easily. Empower+Stop+Redux or Empower+Attenuate+Redux are also incredibly strong. Or, while completely overkill, you could do Matrix+Induce Anomaly+Redux to dump paradox like there's no tomorrow (or have a bunch of chances for useful anomalies to occur).
Attenuate really deserves special mention, because it can eliminate the advantage of enemies with Unstoppable, Heroism infusions, and the like. It's also incredibly effective against enemies that split, since the new copies will still have Attenuate on them, and they may simply die immediately if their health is low enough.
The passive damage reduction on the new Paradox Mage works very well in combination with the fact that it generally takes a couple turns of setup to flatten an entire room. I do miss the old damage smearing combined with high temporal resist, and honestly one of the greatest dangers I faced in my recent winner was the sheer amount of damage I would take if I hit myself with Stop.
Entropy may not be the best sustain removal in the game, but it's still very good. It effectively neuters the most dangerous rares and bosses in short order. One of my only two deaths was in the Shadow Crypt against my clone, and I doubt I would have died if I had thrown entropy at my clone instead of at the orc. My only other death was against Atamathon, because I got cocky and didn't get out of melee range, but I easily killed him after returning to life.
Probably on my next one I'll explore the possibilities of Time Stop and Temporal Reprieve.