Check out Nate's blogpost on the matter : http://te4.org/blogs/nate/2013/03/affli ... rst-cursed
While a little dated, it should still hold true.
Some general advice to get you going: pick Cornac at first, and get the Rampage tree at level 1 - put points in the and bump into stuff. While the first skill is an brilliant damage dealer, it makes for escape. If tings aren't going your way, activate it and run.
The Gloom tree is awesome for making crowds easier. It's tempting to go for some nice damage dealing skills, but DON'T forget this tree.
Find yourself a good regen / healing infusion early. Also look for a movement infusion. (you can use two heal infusions or a heal movement - I prefer the mobility.) Spend your level 10 cat point on an infusion slot.
The senses talent is awesome for knowing what's around a corner - knowing what's lurking makes it easier to not die.
Many of the cursed offensive talents (blindside, the rushing one) are brilliant escapes. Do not forget this.