Just finished for the first time! Without closing any portals, because I didn't know how. Thanks for the guide, and thanks also to the others commenting. The discussion was useful.
1) I feel sorry for anybody who doesn't try out blindside, preternatural senses, and surge. They are just too good to pass-up, and there are enough points to go around.
2) Predator is kind of a wash. I didn't use it, but used it with a previous build. It's moderate benefit, for only some opponents (although, sure, the final bosses), for a lot of investment. Okay for Cornac-- maybe not a good idea for peeps with XP penalties that need to level up to 50 in farportals, where they teleport baddies of all types on either side of you, eight deep, and then send you a random boss with 500% resist all.... (Still have no idea how I killed that thing.)
3) I tried out Fears. I wouldn't do that again. It's pretty useless. You can go through a whole bar of hate, running around, trying to get the fears to take hold in a group, when you could just kill them instead. If you've got a category point and don't know what to do with it, spend it on mastery for one of your other talents. Combat training mastery is a good first choice.
4) The hard part of cursed is the beginning: once you level up a bit, you can easily take on at-level baddies. So the XP penalty isn't a big deal for other races. But fungus is so good, and cursed will have such high WP and such low Magic, it just doesn't seem like a good idea to take a spellcasting race. You don't really need the Cornac category point, but then, you don't really need any racials either.
5) Mindstars would work good for them, if you feel like doing it. (I took out the first boss with a witchblade and an off-hand mindstar, then switched to 2H for the second one.) One of the cool things about cursed is that they can switch between shield, 2H, and dual wield without losing anything, so you might as well look at all the weapons that drop, rather than locking yourself into a particular playstyle. (I still found 2H to be the most useful.)
6) Curses are just not a good investment. Too many points, too dependent on RNG for your gear (practically, you'll be running with slightly subpar gear so you can get the curses to match up), and the early willpower hit hurts for developing talents.
7) Really, it's hard to go wrong with prodigies. I did superpower and fast as lightning (which was fun, but I wouldn't do it again). Pick one that's useful, and you can get away with one that's fun. If I was going to do it over again, I'd probably take superpower and +15% global speed. Or maybe mental tyranny.
Two regens, one heroism, and one movement infusion will give you as many escapes as you need, so long as you're careful when Relentless Pursuit is still on cool-down. I just took a look at my finished character: with surge, rampage, and movement, I'm at 18000% speed. So that movement infusion works as a perfectly controlled teleport to anywhere on the map.
9) The only status effects I had problems with were curse of death, impending doom, and blindness. Cursed status immunities are unparalleled. Between surge and rampage, it was never a problem falling back to wait anything out.