1) always carry a status removal with you.
2) if you are unsure of what enemy is capable of, inspect it (right-click) (or inspect self with C by default)
3) auto use "shot" on left-click on target enemy.
4) It never hurts to take a look at a low lvl zone. (as in, before you go anywhere, check all t1 zones (except for 1 event)).
5) take your time, (and if you are a chronomancer, enemy's too) its a turn based game.
6) when you enter a new area, check everything BEFORE you charge at the boss.
6.1) get some detection. some items come with "track", and don't underestimate a telepathy.
7) you can drawn.
7.1) and so can every (non undead/construct) mob that is not exclusively spawning in an underwater lvl.

most of the runes and infusions scale with a random stat. one that is stronger now, may be weaker later.
8.1) "warrior's" strength, "duellist's" dexterity, "titans" constitution, "wizards" magic, "psychics" willpower, "sneak's" cunning.
8.2) if you think there is even a slightest possibility of you using it, keep it.
9) while escorts always jump into the abyss, the reward is usually worth the trouble.
9.1) especially if its a passive or a sustain.
10) VISION: this game can randomly spawn a rare with powers that counter yours. getting information about the map can often be vital for your survival.
11) if the doors are locked, its probably for a good reason.
12) if you are unsure whether you can delay your healing or not, don't.
12.1) shield runes don't take time to cast.
13) two words - "stats juggling". you will understand as soon as you feel the need to do it.